Via Scoble, I've discovered Onfolio and it looks awesome.
At one level, Onfolio is very similar to where my sister, Jenni and I are headed with a little Python tool we're writing code-named TrIM. Both essentially allow files, links and fragments of information to be managed in an organized collection.
Onfolio has nice integration with IE, which makes it great for web-based information gathering (although it does support dragging-and-dropping of arbitrary files like TrIM). It also has a nice publishing mechanism (including ability to publish information collections as RSS feeds).