Via Scoble, I've discovered Onfolio and it looks awesome.
At one level, Onfolio is very similar to where my sister, Jenni and I are headed with a little Python tool we're writing code-named TrIM. Both essentially allow files, links and fragments of information to be managed in an organized collection.
Onfolio has nice integration with IE, which makes it great for web-based information gathering (although it does support dragging-and-dropping of arbitrary files like TrIM). It also has a nice publishing mechanism (including ability to publish information collections as RSS feeds).
There may be broken links to media on this page. I'm still in the process of migrating them over.